p16
Description
The p16 biomarker is overexpressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease. p16 is a tumor suppressor protein also known as cyclin-dependent kinase inhibitor 2A. The p16 biomarker is overexpressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease.Notes
**Note 1:** **Effective years** * This SSDI is effective for diagnosis years 2023+ * For cases diagnosed 2018-2022, this SSDI must be blank **Note 2:** **p16 Results ONLY** * This data item must be based on testing results for p16 overexpression. * Testing for HPV by DNA, mRNA, antibody, or other methods should not be coded in this data item * Do not confuse p16 with HPV, which is a specific strain of virus. A statement of a patient being HPV positive or negative is not enough to code this data item.| p16 | Description |
|---|---|
| 0 | p16 Negative; Nonreactive |
| 1 | p16 Positive; Diffuse, Strong reactivity |
| 8 | Not applicable: Information not collected for this case (If this time is required by your standard setter, use of code 8 will result in an edit error) |
| 9 | Not tested for p16; Unknown |
| <BLANK> | Must be blank if diagnosis year is before 2023 |