SITE SPECIFIC DATA ITEMS (SSDI)/ GRADE

Description

Estrogen Receptor Total Allred Score is based on the percentage of cells that stain positive by IHC for estrogen receptor (ER) and the intensity of that staining. The Allred Score is a method of quantifying ER and PR using both intensity and percentage of positive cells. The Allred Score is calculated by adding the Proportion Score and the Intensity Score, as defined in the tables below. The Allred score combines the percentage of positive cells (proportion score) and the intensity score of the reaction product in most of the carcinoma. The 2 scores are added together for a final score with 8 possible values (00-08). Positive cells = 0; Proportion score = 0 Positive cells = <1; Proportion score = 1 Positive cells = 1 to 10; Proportion score = 2 Positive cells = 11 to 33; Proportion score = 3 Positive cells = 34 to 66; Proportion score = 4 Positive cells = 67 or greater; Proportion score = 5 Intensity = None; Intensity Score = 0 Intensity = Weak; Intensity Score = 1 Intensity = Intermediate/Moderate; Intensity Score = 2 Intensity = Strong; Intensity Score = 3

Notes

**Note 1:** **No longer required by any standard setter** * This SSDI is no longer required by any of the standard setters starting with 2023 diagnoses * For cases diagnosed 2023+, this SSDI may be left blank **Note 2:** **Physician Statement** * Physician statement of ER (Estrogen Receptor) Total Allred Score can be used to code this data item. **Note 3:** **Related data item** * Code this data item using the same report used to record the related data item 3827: Estrogen Receptor Summary.