HER2 Overall Summary
This input is used for staging
Notes**Note 1:** Physician statement of HER2 Overall Summary can be used to code this data item when no other information is available. **Note 2:** The result of the HER2 test performed on the primary breast tissue is to be recorded in this data item. **Note 3:** Results from nodal or metastatic tissue may be used **ONLY** when there is no evidence of in situ or invasive carcinoma in the primary tumor. **Note 4:** In cases where there are invasive and in situ components in the primary tumor and HER2 is done on both, ignore the in situ results. * If HER2 is positive on an in situ component and HER2 is negative on all tested invasive components in the primary tumor, code HER2 as negative (code 0) * If in situ and invasive components present and HER2 only done on the in situ component in the primary tumor, code unknown (code 9) **Note 5:** In cases where there is a single tumor with multiple biopsies and/or surgical resection with different HER2 results. * Use the highest (positive versus negative) **Note 6:** In cases where there are multiple tumors with different HER2 results, code the results from the largest tumor size (determined either clinically or pathologically) when multiple tumors are present. * Do not use specimen size to determine the largest tumor size **Note 7:** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no HER2 results from pre-treatment specimens, report the findings from post-treatment specimens **Note 8:** If the patient is HER2 positive and node negative, a multigene test such as Oncotype Dx may be performed, in which case another HER2 test will be performed. Do not record the results of that test in this field. * Record only the results of the test which made the patient eligible to be given the multigene test **Note 9:** HER2 is not routinely done on pure in situ tumors (behavior /2); however, if you have an in situ tumor and there are HER2 results, go ahead and record it. Otherwise code 9.
|0||HER2 negative; equivocal|
|7||Test ordered, results not in chart|
|9||Not documented in medical record
Cannot be determined (indeterminate)
HER2 Overall Summary status not assessed or unknown if assessed