PD-L1
Description
The absence or presence of PD-L1 expression determines if the tumor will respond to treatment with a targeted inhibitor (immunotherapy). PD-L1 is done for Non-Small Cell lung cancers (NSCLC). This test is usually done on metastatic non-small cell lung cancer (NSCLC) patients. An assay is performed on formalin-fixed, paraffin-embedded (FFPE) tissue specimen of at least 100 cells taken from the patient. The assay is used to determine the PD-L1 expression by IHC. Then the pathologist determines the tumor proportion score. The treating physician uses that information to determine what type of treatment the patient will receive.Notes
**Note 1:** **Effective years** * This SSDI is effective for diagnosis years 2025+ * For cases diagnosed 2018-2024, this SSDI must be blank **Note 2:** **Physician Statement** * Physician statement PD-L1 can be used to code this data item when no other information is available. **Note 3:** **Purpose of PD-L1** * The absence or presence of PD-L1 expression determines if the tumor will respond to treatment with a targeted inhibitor (immunotherapy). PD-L1 is done for Non-Small Cell lung cancers (NSCLC). **Note 4:** **Tumor Proportion Score** * PD-L1 is documented by the tumor proportion score. Record the actual Tumor Proportion Score (0.0-100.0) as stated from the pathology report. * An actual tumor proportion score (.1-100.0) takes priority over XXX.2 (Stated as negative), XXX.3 (Stated as low), or XXX.4 (Stated as high/positive) **Note 5:** **Neoadjuvant therapy** If neoadjuvant therapy is given, record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no PD-L1 results from pre-treatment specimens, report the findings from post-treatment specimens| Code | Description |
|---|---|
| 0.0 | No PD-L1 expression identified Tumor Proportion Score (TPS) = 0% |
| 0.1-100.0 | 0.1-100.0 PD-L1 expression Tumor Proportion Score (TPS) = 0.1%-100.0% |
| XXX.2 | PD-L1 expression absent **AND** Tumor Proportion Score (TPS) stated as negative |
| XXX.3 | PD-L1 expression present **AND** Tumor Proportion Score (TPS) stated as low |
| XXX.4 | PD-L1 expression present **AND** Tumor Proportion Score (TPS) stated as high/positive |
| XXX.7 | Test ordered, results not in chart |
| XXX.8 | Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 8 will result in an edit error) |
| XXX.9 | Not documented in medical record No microscopic confirmation of tumor PD-L1 cannot be determined PD-L1 not assessed or unknown if assessed |
| <BLANK> | N/A - Diagnosis year is prior to 2025 |