Brain Molecular Markers
Notes
**Note 1:** This data item was introduced in 2018 and applied to the following ICD-O-3 histology codes 9400/3, 9401/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3 * These are codes 01-09 and are applicable for cases diagnosed 2018+ and are in ICD-O-3 order **Note 2:** In 2022, the 5th edition of the CNS WHO Blue Book was released and the following histologies were added 9385/3, 9396/3, 9421/1, 9430/3, 9500/3 * These are codes 10-23 and are applicable for cases diagnosed 2024+ and are in ICD-O-3 order **Note 3:** If a microscopically confirmed histology is not included in this list, assign, code 85. * If your case is not microscopically confirmed, code 99 **Note 4:** Physician statement of histologic subtype can be used to code this data item. **Note 5:** See Brain Molecular Markers in the SSDI Manual, in the *Definition* section for more information on the different histologies. ***Examples:*** 1. Biopsy of brain tumor, microscopic confirmation diagnosis: Diffuse Astrocytoma (9400/3). Additional testing done, and IDH-mutant is identified. Code 01. 2. Biopsy of brain tumor, microscopic confirmation diagnosis: Anaplastic astrocytoma (9401/3). No further testing or results unknown. Code 99. 3. MRI of brain tumor, clinical diagnosis: glioblastoma. No further workup. Code 99. 4. Biopsy of brain tumor, microscopic confirmation diagnosis: Mixed glioma (9382/3). Code 85.| Code | ICD-O-3 Code | ICD-O-Description |
|---|---|---|
| 01 | 9400/3 | Astrocytoma, IDH-mutant, grade 2 |
| 02 | 9400/3 | Diffuse astrocytoma, IDH-wildtype |
| 03 | 9401/3 | Astrocytoma, IDH-mutant, grade 3 |
| 04 | 9401/3 | Anaplastic astrocytoma, IDH-wildtype |
| 05 | 9440/3 | Glioblastoma, IDH-wildtype |
| 06 | 9450/3 | Oligodendroglioma, IDH-mutant and 1 p/19q co-deleted |
| 07 | 9451/3 | Oligodendroglioma, IDH-mutant and 1p/19q co-deleted, grade 3 |
| 08 | 9471/3 | Medulloblastoma, SHH-activated and TP53-wildtype |
| 09 | 9478/3 | Embryonal tumor with multilayered rosettes, C19MC-altered |
| 10 | 9385/3 | Diffuse hemispheric glioma, H3-34 mutant |
| 11 | 9385/3 | Diffuse midline glioma, H3 K27-altered |
| 12 | 9385/3 | Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype |
| 13 | 9385/3 | Infant-type hemispheric glioma |
| 14 | 9396/3 | Posterior fossa group A (PFA) ependymoma |
| 15 | 9396/3 | Posterior fossa group B (PFB) ependymoma |
| 16 | 9396/3 | Spinal ependymoma, MYCN-amplified |
| 17 | 9396/3 | Supratentorial ependymoma, YAP1 fusion-positive |
| 18 | 9396/3 | Supratentorial ependymoma, ZFTA fusion-positive |
| 19 | 9421/1 | Diffuse astrocytoma, MYB- or MYBL1-altered |
| 20 | 9421/1 | Diffuse low-grade glioma, MAPK pathway-altered |
| 21 | 9430/3 | Astroblastoma, MN1-altered |
| 22 | 9500/3 | CNS neuroblastoma, FOXR2-activated |
| 23 | 9500/3 | CNS tumor BCOR internal tandem duplication |
| 85 | NA | Not applicable: Histology not 9385/3, 9396/3, 9400/3, 9401/3, 9430/3, 9440/3, 9450/3, 9451/3, 9471/3, 9478/3, 9421/1, 9430/3, 9500/3 |
| 86 | NA | Benign or borderline tumor Excludes: 9421/1 (codes 19-20) |
| 87 | NA | Test ordered, results not in chart |
| 88 | NA | Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code 88 will result in an edit error.) |
| 99 | NA | Not documented in medical record No microscopic confirmation Brain molecular markers not assessed or unknown if assessed |