Data Last Updated: Oct. 15, 2024

Chromosome 3 Status

Description

Chromosome 3 Status refers to the partial or total loss of Chromosome 3, which is a prognostic factor for uveal melanoma. The loss of an entire copy of chromosome 3, which occurs in about half of patients, is the most important indicator of poor prognosis for the uveal melanomas, particularly melanoma of the choroids and ciliary body. A variety of sophisticated tests can be used to determine chromosome 3 status. * Karyotyping * Fluorescence in situ hybridization * Comparative genomic hybridization * DNA polymorphism analysis (e.g., single nucleotide polymorphism, microsatellite) * Multiplex ligation probe amplification * Monosomy 3 means loss of chromosome 3. Determination of chromosome status may be affected by prior irradiation Monosomy 3, especially if combined with a frequently coexisting gain in chromosome 8q, is independently associated with metastatic risk. Chromosome 3 and 8 statuses may be determined with karyotyping or fluorescent in situ hybridization (FISH).

Notes

**Note 1:** **Physician Statement** * Physician statement of chromosome 3 status can be used to code this data item when no other information is available. **Note 2:** **Related data item** * See related data item 3822: Chromosome 8q Status.
Code Description
0 No loss of chromosome 3
1 Partial loss of chromosome 3
2 Complete loss of chromosome 3
3 Loss of chromosome 3, NOS
Loss of BAP1 expression
7 Test ordered, results not in chart
8 Not applicable: Information not collected for this case
(If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record
Chromosome 3 status not assessed or unknown if assessed