Ki-67
Description
Ki-67 (MIB-1) (Proliferative Index) is a marker of cell proliferation. A high value indicates a tumor that is proliferating more rapidly. Codes and coding instructions for this data item are site-specific.Notes
**Note 1:** **Effective years** * This SSDI is effective for diagnosis years 2021+ * For cases diagnosed 2018-2020, this SSDI must be blank **Note 2:** **Physician Statement** * Physician statement of Ki-67 (MIB-1), also referred to as the “Proliferative Index,” can be used to code this data item when no other information is available **Note 3:** **Priority order** * A specific value (0.0-100.0) takes priority over XXX.4, XXX.5 or XXX.6. * Code the exact percentage when provided * When the exact percentage is not given, including ranges or terms such as “less than” or “greater than” use the range value codes XXX.4, XXX.5, XXX.6. * XXX.4, XXX.5 and XXX.6 were added since they are listed on the CAP protocol **Note 4:** **Results from nodal or metastatic tissue** * May **not** be used * If the only information you have is a Ki-67 from a metastatic site, code to XXX.9 **Note 5:** **Neoadjuvant Therapy** * Record the assay from tumor specimens prior to neoadjuvant therapy. * If neoadjuvant therapy is given and there are no HER2 ISH results from pre-treatment specimens, report the findings from post-treatment specimens.| Code | Description |
|---|---|
| 0.0-100.0 | 0.0 to 100.0 percent positive: enter percent positive |
| XXX.4 | Ki-67 stated as less than 3% |
| XXX.5 | Ki-67 stated as 3%-20% |
| XXX.6 | Ki-67 stated as greater than 20% |
| XXX.7 | Test done; actual percentage not stated |
| XXX.8 | Not applicable: Information not collected for this case (If this item is required by your standard setter, use of code XXX.8 will result in an edit error.) |
| XXX.9 | Not documented in medical record Ki-67 (MIB-1) not assessed or unknown if assessed |
| <BLANK> | Must be blank if diagnosis year is before 2021 |