Grade Post Therapy Clin (yc)
Notes
**Note 1:** Leave Grade Post Therapy Clin (yc) blank when * No neoadjuvant therapy * Clinical or pathological case only * Neoadjuvant therapy completed, no microscopic exam is done prior to surgery/resection of primary tumor * There is only one grade available and it cannot be determined if it is clinical, pathological, post therapy clinical or post therapy pathological **Note 2:** Assign the highest grade from the microscopically sampled specimen of the primary site following neoadjuvant therapy or primary systemic/radiation therapy. **Note 3:** If there are multiple tumors with different grades abstracted as one primary, code the highest grade. **Note 4:** Codes 1-5 take priority over A-E. **Note 5:** For prostate, TURP or simple prostatectomy qualify for a clinical grade only. **Note 6:** Code 9 (unknown) when * Microscopic exam is done after neoadjuvant therapy and grade from the primary site is not documented * Microscopic exam is done after neoadjuvant therapy and there is no residual cancer * Grade checked “not applicable” on CAP Protocol (if available) and no other grade information is available **Note 7:** If you are assigning an AJCC Staging System stage group * Grade is required to assign stage group * Codes A-E are treated as an unknown grade when assigning AJCC stage group * An unknown grade may result in an unknown stage group| Code | Description |
|---|---|
| 1 | Grade Group 1: Gleason score less than or equal to 6 |
| 2 | Grade Group 2: Gleason score 7 Gleason pattern 3+4 |
| 3 | Grade Group 3: Gleason score 7 Gleason pattern 4+3 |
| 4 | Grade Group 4: Gleason score 8 |
| 5 | Grade Group 5: Gleason score 9 or 10 |
| A | Well differentiated |
| B | Moderately differentiated |
| C | Poorly differentiated |
| D | Undifferentiated, anaplastic |
| E | Stated as "Gleason score 7" with no patterns documented or Any Gleason patterns combination equal to 7 not specified in 2 or 3 |
| 9 | Grade cannot be assessed; Unknown |
| <BLANK> | See Note 1 |