Data Last Updated: June 9, 2025

NAACCR Item #3885: Lymphocytosis

Item # Length Source of Standard Section Name Year Implemented Version Implemented XML NAACCR ID Parent XML Element
3885 1 NAACCR Stage/Prognostic Factors 2018 18 lymphocytosis Tumor
Required Status:

NPCR Collect: No recommendation
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: Required, site specific; when available

Description
Lymphocytosis is defined by an excess of lymphocytes in the blood. In staging of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), lymphocytosis is defined as an absolute lymphocyte count (ALC) greater than 5,000 cells/µL.
Rationale
Lymphocytosis is a prognostic factor required for staging of Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLL) in AJCC 8th edition, Chapter 79, *Hodgkin and Non-Hodgkin Lymphomas*.
Allowable Values
0, 1, 5, 6, 7, 9
Codes
Code Description
0 Lymphocytosis not present Absolute lymphocyte count = 5,000 cells/µL
1 Lymphocytosis present Absolute lymphocyte count > 5,000 cells/µL
5 Not applicable: Primary site is not C421
6 Lab value unknown, physician states lymphocytosis is present Physician states Rai stage 0-IV
7 Test ordered, results not in chart
9 Not documented in medical record Lymphocytosis not assessed or unknown if assessed No Rai stage is documented in the record and there is no documentation of lymphocytosis
Code Notes
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.