NAACCR Item #3890: Microsatellite Instability (MSI)
| Item # | Length | Source of Standard | Section Name | Year Implemented | Version Implemented | XML NAACCR ID | Parent XML Element |
|---|---|---|---|---|---|---|---|
| 3890 | 1 | NAACCR | Stage/Prognostic Factors | 2018 | 18 | microsatelliteInstability | Tumor |
Required Status:
NPCR Collect: Required, site specific; when available
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: Required, site specific; when available
Description
Microsatellite Instability (MSI) is a form of genetic instability manifested by changes in the length of repeated single- to six-nucleotide sequences (known as DNA microsatellite sequences). High MSI, found in about 15% of colorectal carcinomas, is an adverse prognostic factor for colorectal carcinomas and predicts poor response to 5-FU chemotherapy (although the addition of oxaliplatin in FOLFOX regimens negates the adverse effects [page 266 AJCC manual]). High MSI is a hallmark of hereditary nonpolyposis colorectal carcinoma, also known as Lynch syndrome.
Rationale
Microsatellite Instability (MSI) is a Registry Data Collection Variable in AJCC. It was previously collected as Colon and Rectum, CS SSF# 7.
Allowable Values
0-2, 8, 9
Codes
| Code | Description |
|---|---|
| 0 | Microsatellite instability (MSI) stable; microsatellite stable (MSS); negative, NOS AND/OR Mismatch repair (MMR) intact, no loss of nuclear expression of MMR proteins MMR proficient (pMMR or MMR-P) |
| 1 | MSI unstable low (MSI-L) |
| 2 | MSI unstable high (MSI-H) AND/OR MMR deficient (dMMR or MMR-D), loss of nuclear expression of one or more MMR proteins |
| 8 | Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.) |
| 9 | Not documented in medical record MSI-indeterminate MSI-equivocal Microsatellite instability not assessed or unknown if assessed |
Code Notes
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.