Data Last Updated: June 9, 2025

NAACCR Item #3909: Perineural Invasion

Item # Length Source of Standard Section Name Year Implemented Version Implemented XML NAACCR ID Parent XML Element
3909 1 NAACCR Stage/Prognostic Factors 2018 18 perineuralInvasion Tumor
Required Status:

NPCR Collect: No recommendation
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: No recommendation

Description
Perineural Invasion, within or adjacent to the primary tumor, is a negative prognostic factor for cutaneous squamous cell carcinomas of the head and neck and carcinomas of the colon and rectum, eyelid and lacrimal gland.
Rationale
Perineural Invasion is a Registry Data Collection Variable in AJCC. It was previously collected as Colon and Rectum CS SSF# 8 and Lacrimal Gland CS SSF# 4.
Allowable Values
0, 1, 8, 9
Codes
Code Description
0 Perineural invasion not identified/not present
1 Perineural invasion identified/present
8 Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record Pathology report does not mention perineural invasion Cannot be determined by the pathologist Perineural invasion not assessed or unknown if assessed
Code Notes
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.