Data Last Updated: June 9, 2025

NAACCR Item #3918: Profound Immune Suppression

Item # Length Source of Standard Section Name Year Implemented Version Implemented XML NAACCR ID Parent XML Element
3918 1 NAACCR Stage/Prognostic Factors 2018 18 profoundImmuneSuppression Tumor
Required Status:

NPCR Collect: No recommendation
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: No recommendation

Description
Profound Immune Suppression, suppressed immune status that may be associated with HIV/AIDs, solid organ transplant, chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple conditions or other conditions, increases the risk of developing Merkel Cell Carcinoma and is an adverse prognostic factor.
Rationale
Profound Immune Suppression is a Registry Data Collection Variable in AJCC. It was previously collected as Merkel Cell Penis, SSF #22, Merkel Cell Scrotum SSF #22, Merkel Cell Skin, SSF# 22, and Merkel Cell Vulva, SSF# 22.
Allowable Values
0-6, 8, 9
Codes
Code Description
0 No immune suppression condition(s) identified/not present
1 Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS)
2 Solid organ transplant recipient
3 Chronic lymphocytic leukemia
4 Non-Hodgkin lymphoma
5 Multiple immune suppression conditions
6 Profound immune suppression present
8 Not applicable: Information not collected for this case (If this information is required by your standard setter, use of code 8 may result in an edit error.)
9 Not documented in medical record Profound immune suppression not assessed or unknown if assessed
Code Notes
Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.