Data Last Updated: June 9, 2025

NAACCR Item #3924: S Category Pathological

Item # Length Source of Standard Section Name Year Implemented Version Implemented XML NAACCR ID Parent XML Element
3924 1 NAACCR Stage/Prognostic Factors 2018 18 sCategoryPathological Tumor
Required Status:

NPCR Collect: No recommendation
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: Required, site specific; when available

Description
S Category Pathological combines the results of post-orchiectomy Alpha Fetoprotein (AFP), Human Chorionic Gonadotropin (hCG) and Lactate Dehydrogenase (LDH) into a summary S value.
Rationale
S Category Pathological is required for prognostic stage grouping in AJCC 8th edition, Chapter 59, *Testis*. It is a new data item for cases diagnosed 1/1/2018+.
Allowable Values
0-3, 5, 9
Codes
Code Description
0 S0: Marker study levels within normal levels
1 S1: At least one of these values is elevated AND LDH less than 1.5 x N\* AND hCG (mIU/L) less than 5,000 AND AFP (ng/mL) less than 1,000
2 S2 LDH 1.5 x N\* to 10 x N\* OR hCG (mIU/L) 5,000 to 50,000 OR AFP (ng/mL) 1,000 to 10,000
3 S3: Only one elevated test is needed LDH greater than 10 x N\* OR hcG (mIU/mL) greater than 50,000 OR AFP (ng/mL) greater than 10,000
5 Post orchiectomy serum tumor markers unknown or not done but pre orchiectomy serum tumor markers were normal
9 SX: Not documented in medical record S Category Pathological not assessed or unknown if assessed
Code Notes
\*N indicates the upper limit of normal for the LDH assay.   Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.