NAACCR Item #3956: p16
| Item # | Length | Source of Standard | Section Name | Year Implemented | Version Implemented | XML NAACCR ID | Parent XML Element |
|---|---|---|---|---|---|---|---|
| 3956 | 1 | SEER | Stage/Prognostic Factors | 2022 | 22 | p16 | Tumor |
Required Status:
NPCR Collect: Required, site specific
CoC Collect: Required, site specific
SEER Collect: Required, site specific
CCCR Collect: Required, site specific; when available
Description
The p16 biomarker is over-expressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease.
Rationale
Patients with HPV have a different survival or outcome so it is important to be able to distinguish this by documenting the p16 results. Testing is performed by immunohistochemistry (IHC) which is inexpensive and has near universal availability. It has an easily standardized interpretation. HPV testing is usually performed through DNA testing which is more expensive and less widely available. HPV testing also has technically more variability with the interpretation.
Notes
p16 is a tumor suppressor protein also known as cyclin-dependent kinase inhibitor 2A. The p16 biomarker is over-expressed (produced) in response to HPV. It is therefore a surrogate marker for HPV disease.
Allowable Values
0, 1, 8, 9, blank
Codes
| Code | Description |
|---|---|
| 0 | p16 Negative; Nonreactive |
| 1 | p16 Positive; Diffuse, Strong reactivity |
| 8 | Not applicable: Information not collected for this case (If this time is required by your standard setter, use of code 8 will result in an edit error). |
| 9 | Not tested for p16; Unknown |
| Blank | Diagnosis year prior to 2024 |
Code Notes
Note: See the [SSDI Manual](https://apps.naaccr.org/ssdi/list/?_gl=1*111s1ff*_ga*NTAyNDk1MDUwLjE1OTI5Mzk3MDY.*_ga_ZGX07SVHJF*MTY1NDU0NDUzMy40LjEuMTY1NDU0NDcwNi4w&_ga=2.89925727.598791132.1654524231-502495050.1592939706) for coding instructions.
Anus schema added/ Please note for CCCR p16 for Cervix changed from "." to RS\* retroactive to 2021