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Data Standards and Data Dictionary

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Length: 1
Source of Standard: NAACCR/SEER
Section Name: Stage/Prognostic Factors
Year Implemented: 2025
Version Implemented: 25
Record Types: C, A, I, M

XML NAACCR ID: inpc

Parent XML Element: Tumor

Alternate Names:

  • International Neuroblastoma Pathology Prognostic Classification (INPC)
  • Shimada Classification
  • Unfavorable histology, or Favorable histology

Required Status:

NPCR Collect: . - No recommendations
CoC Collect: . - No recommendations
SEER Collect: RS* - Required, site specific; when available
CCCR Collect: . - No recommendations

Description:

The International Neuroblastoma Pathology Prognostic Classification (INPC) categorizes neuroblastomas as favorable or unfavorable histologies based on the following factors: age, neuroblastic maturation, Schwannian stromal content, Mitosis-kayorrhexis index (MKI), and degree of differentiation (grade). 

The International Neuroblastoma Pathology Prognostic Classification (INPC) (unfavorable versus favorable histology) is a biologically relevant classification based on morphologic features of neuroblastic tumors which has prognostic indications. It is based on the following criteria

  • Age
  • Neuroblastic maturation
  • Schwannian stromal content
  • Mitosis-kayorrhexis index (MKI)
  • Degree of differentiation (grade)

Rationale:

This is part of the National Childhood Cancer Registry (NCCR) project to collect more specific information on pediatric patients. Registries part of the NCCR will start collection on specific pediatric data items with 2024+ diagnoses.

General Notes:

Source documents: pathology report

Item Data Type:

digits

Allowable Values

0, 1, 7, 8, 9

Codes:

For further information, refer to the Neuroblastoma cancer protocol published by the College of American Pathologists

0

Unfavorable

1

Favorable

7

Test ordered, results not in chart

8

Not applicable: Information not collected for this case

(If this information is required by your standard setter, use of code 8 may result in an edit error)

9

Not documented in medical record

Cannot be determined by pathologist

International Neuroblastoma Pathology Prognostic Classification (INPC) not assessed or unknown if assessed

INPC assessed only at post neoadjuvant surgical resection

Code Notes:

Note 1: Effective years

  • This SSDI is effective for diagnosis years 2024+
  • For cases diagnosed 2018-2023, this SSDI must be blank

Note 2: Physician statement

  • Physician statement of unfavorable vs favorable histology can be used to code this data item when no other information is available, provided there is information that the results are from a biopsy or surgical resection without neoadjuvant therapy.

Note 3: Neoadjuvant Therapy

  • The INPC results are to be coded based on either biopsy or surgical resection (without neoadjuvant therapy).
  • Code 9 if the only results are from a post neoadjuvant surgical resection.