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NAACCR Data Dictionary
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Version 26
Data Item #3941: NRAS Mutational Analysis

* indicates required field

Length: 1
Source of Standard: NAACCR
Section Name: Stage/Prognostic Factors
Year Implemented: 2021
Version Implemented: 21
Record Types: A , M , C , I

XML NAACCR ID: nrasMutationalAnalysis

Parent XML Element: Tumor

Required Status:

NPCR Collect: . - No recommendations
CoC Collect: RS - Required, site specific
SEER Collect: R - Required
CCCR Collect: . - No recommendations

Description:

NRAS is a signaling intermediate in the growth receptor pathway. Certain NRAS mutations predict poor response to anti-EGFR therapy in patients with metastatic colorectal cancer.

Rationale:

NRAS mutational analysis is recommended in clinical guidelines for patients with metastatic colon cancer who are being considered for anti-EGFR therapy. It is a new data item for cases diagnosed 01/01/2021+.

Item Data Type:

text

Allowable Values

0-2, 4, 7-9

Codes:

0

Normal
NRAS negative; NRAS wild type
Negative for (somatic) mutations, no alterations, no (somatic) mutations identified, not present, not detected

1

Abnormal (mutated)/detected in codon(s) 12, 13, and/or 61

2

Abnormal (mutated)/detected, codon(s) specified but not in codon(s) 12, 13, or 61

4

Abnormal (mutated), NOS, codon(s) not specified

7

Test ordered, results not in chart

8

Not applicable: Information not collected for this case
If this information is required by your standard setter, use of code 8 may result in an edit error.

9

Not documented in medical record
NRAS not assessed or unknown if assessed

Code Notes:

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.